Design, synthesis and pharmacological evaluation of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl)quinoline derivatives as antitumor agents: in vitro and in vivo antitumor activity, cell cycle arrest and apoptotic response

A series of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl)quinoline derivatives (3a(1)−3d(6)) were designed and synthesized as antitumor agents. In vitro antitumor assay results showed that some compounds exhibited moderate to high inhibitory activities against HepG2, SK-OV-3, NCI-H460 and BEL-7404 tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuang, Wen-Bin, Huang, Ri-Zhen, Fang, Yi-Lin, Liang, Gui-Bin, Yang, Chen-Hui, Ma, Xian-Li, Zhang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082043/
https://www.ncbi.nlm.nih.gov/pubmed/35539175
http://dx.doi.org/10.1039/c8ra04640a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082043/
https://www.ncbi.nlm.nih.gov/pubmed/35539175
http://dx.doi.org/10.1039/c8ra04640a

Ejemplares similares