Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands

A series of 3-triazole-thiogalactosides and 3,3′-triazole-thiodigalactosides substituted with different five-membered heterocycles at the C-4 triazole position were found to have high selectivity for galectin-1. Initial studies on the 3-triazole-thiogalactosides indicated that five membered heterocy...

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Detalles Bibliográficos
Autores principales: Peterson, Kristoffer, Collins, Patrick M., Huang, Xiaoli, Kahl-Knutsson, Barbro, Essén, Sofia, Zetterberg, Fredrik R., Oredsson, Stina, Leffler, Hakon, Blanchard, Helen, Nilsson, Ulf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082524/
https://www.ncbi.nlm.nih.gov/pubmed/35542159
http://dx.doi.org/10.1039/c8ra04389b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082524/
https://www.ncbi.nlm.nih.gov/pubmed/35542159
http://dx.doi.org/10.1039/c8ra04389b

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