Novel indole based hybrid oxadiazole scaffolds with N-(substituted-phenyl)butanamides: synthesis, lineweaver–burk plot evaluation and binding analysis of potent urease inhibitors

In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4) as a nucleophile. In the second phase, variou...

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Detalles Bibliográficos
Autores principales: Nazir, Majid, Abbasi, Muhammad Athar, Aziz-ur-Rehman, Siddiqui, Sabahat Zahra, Raza, Hussain, Hassan, Mubashir, Ali Shah, Syed Adnan, Shahid, Muhammad, Seo, Sung-Yum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082783/
https://www.ncbi.nlm.nih.gov/pubmed/35541970
http://dx.doi.org/10.1039/c8ra04987d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082783/
https://www.ncbi.nlm.nih.gov/pubmed/35541970
http://dx.doi.org/10.1039/c8ra04987d

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