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An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

BACKGROUND: A genome-wide association study (GWAS) correlates variation in the genotype with variation in the phenotype across a cohort, but the causal gene mediating that impact is often unclear. When the phenotype is protein abundance, a reasonable hypothesis is that the gene encoding that protein...

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Detalles Bibliográficos
Autores principales: Fauman, Eric B., Hyde, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082853/
https://www.ncbi.nlm.nih.gov/pubmed/35527238
http://dx.doi.org/10.1186/s12859-022-04706-x