Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds

BACKGROUND: In eye-drop drug development, the additional genotoxicity tests in some cases might be necessary to assess genotoxicity in the ocular surface since the ocular surface is exposed directly to high drug concentrations. Recently, an in vivo comet assay using corneal epithelial cells in rabbi...

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Detalles Bibliográficos
Autores principales: Tahara, Haruna, Yamagiwa, Yoshinori, Haranosono, Yu, Kurata, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082918/
https://www.ncbi.nlm.nih.gov/pubmed/35527291
http://dx.doi.org/10.1186/s41021-022-00243-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082918/
https://www.ncbi.nlm.nih.gov/pubmed/35527291
http://dx.doi.org/10.1186/s41021-022-00243-4

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