Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Introduction: Early identification of cardiac risk is essential for reducing late-stage attrition in drug development. We adapted the previously published cardiac hazard risk-scoring system using a calcium transient assay in human stem cell-derived CMs for the identification of cardiac risks recorde...

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Detalles Bibliográficos
Autores principales: Lu, Hua Rong, Kreir, Mohamed, Karel, Van Ammel, Tekle, Fetene, Geyskens, Danny, Teisman, Ard, Gallacher, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083324/
https://www.ncbi.nlm.nih.gov/pubmed/35547580
http://dx.doi.org/10.3389/fphys.2022.838435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083324/
https://www.ncbi.nlm.nih.gov/pubmed/35547580
http://dx.doi.org/10.3389/fphys.2022.838435

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