Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis

The pharmacologic effect(s) of biotherapeutics directed against soluble targets are driven by the magnitude and duration of free target suppression at the tissue site(s) of action. Interleukin (IL)-17A is an inflammatory cytokine that plays a key role in the pathogenesis of psoriasis. In this work,...

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Detalles Bibliográficos
Autores principales: Ayyar, Vivaswath S., Lee, Jong Bong, Wang, Weirong, Pryor, Meghan, Zhuang, Yanli, Wilde, Thomas, Vermeulen, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083543/
https://www.ncbi.nlm.nih.gov/pubmed/35548359
http://dx.doi.org/10.3389/fphar.2022.862291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083543/
https://www.ncbi.nlm.nih.gov/pubmed/35548359
http://dx.doi.org/10.3389/fphar.2022.862291

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