Combining enabling formulation strategies to generate supersaturated solutions of delamanid: In situ salt formation during amorphous solid dispersion fabrication for more robust release profiles

Poor solubility is a major challenge that can limit the oral bioavailability of many drugs, including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat tuberculosis. Amorphous solid dispersion (ASD) can improve the bioavailability of poorly water-soluble compounds, yet...

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Detalles Bibliográficos
Autores principales: Duong, Tu Van, Nguyen, Hanh Thuy, Taylor, Lynne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084191/
https://www.ncbi.nlm.nih.gov/pubmed/35413402
http://dx.doi.org/10.1016/j.ejpb.2022.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084191/
https://www.ncbi.nlm.nih.gov/pubmed/35413402
http://dx.doi.org/10.1016/j.ejpb.2022.04.002

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