Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug. A1 is activated by tensile force on VWF concatemers imparted by hydrodynamic drag force. The A1 core is protected from fo...

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Detalles Bibliográficos
Autores principales: Bonazza, Klaus, Iacob, Roxana E, Hudson, Nathan E, Li, Jing, Lu, Chafen, Engen, John R, Springer, Timothy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084892/
https://www.ncbi.nlm.nih.gov/pubmed/35532124
http://dx.doi.org/10.7554/eLife.75760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084892/
https://www.ncbi.nlm.nih.gov/pubmed/35532124
http://dx.doi.org/10.7554/eLife.75760

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