A CRISPR-p53 interactome with potential implications for clinical CRISPR/Cas9 use

CRISPR/Cas9-based tools are anticipated to transform the gene therapy field by facilitating the correction of disease-causing mutations. However, CRISPR/Cas9 generates DNA damage, which triggers a DNA damage response centered around the tumor-suppressor p53. In this research perspective, we discuss...

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Detalles Bibliográficos
Autores principales: Jiang, Long, Wermeling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084925/
https://www.ncbi.nlm.nih.gov/pubmed/35548777
http://dx.doi.org/10.18632/oncoscience.557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084925/
https://www.ncbi.nlm.nih.gov/pubmed/35548777
http://dx.doi.org/10.18632/oncoscience.557

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