Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism. Most pancreatic cancers are classified as pancre...

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Detalles Bibliográficos
Autores principales: McCubrey, James A., Meher, Akshaya K., Akula, Shaw M., Abrams, Stephen L., Steelman, Linda S., LaHair, Michelle M., Franklin, Richard A., Martelli, Alberto M., Ratti, Stefano, Cocco, Lucio, Barbaro, Fulvio, Duda, Przemysław, Gizak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085237/
https://www.ncbi.nlm.nih.gov/pubmed/35477123
http://dx.doi.org/10.18632/aging.204038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085237/
https://www.ncbi.nlm.nih.gov/pubmed/35477123
http://dx.doi.org/10.18632/aging.204038

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