Structural modification of oridonin via DAST induced rearrangement

A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precurso...

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Autores principales: Luo, Dong-Dong, Peng, Kai, Yang, Jia-Yu, Piyachaturawat, Pawinee, Saengsawang, Witchuda, Ao, Lei, Zhao, Wan-Zhou, Tang, Yu, Wan, Sheng-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085272/
https://www.ncbi.nlm.nih.gov/pubmed/35547324
http://dx.doi.org/10.1039/c8ra05728a
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author Luo, Dong-Dong
Peng, Kai
Yang, Jia-Yu
Piyachaturawat, Pawinee
Saengsawang, Witchuda
Ao, Lei
Zhao, Wan-Zhou
Tang, Yu
Wan, Sheng-Biao
author_facet Luo, Dong-Dong
Peng, Kai
Yang, Jia-Yu
Piyachaturawat, Pawinee
Saengsawang, Witchuda
Ao, Lei
Zhao, Wan-Zhou
Tang, Yu
Wan, Sheng-Biao
author_sort Luo, Dong-Dong
collection PubMed
description A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.
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spelling pubmed-90852722022-05-10 Structural modification of oridonin via DAST induced rearrangement Luo, Dong-Dong Peng, Kai Yang, Jia-Yu Piyachaturawat, Pawinee Saengsawang, Witchuda Ao, Lei Zhao, Wan-Zhou Tang, Yu Wan, Sheng-Biao RSC Adv Chemistry A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor. The Royal Society of Chemistry 2018-08-20 /pmc/articles/PMC9085272/ /pubmed/35547324 http://dx.doi.org/10.1039/c8ra05728a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Luo, Dong-Dong
Peng, Kai
Yang, Jia-Yu
Piyachaturawat, Pawinee
Saengsawang, Witchuda
Ao, Lei
Zhao, Wan-Zhou
Tang, Yu
Wan, Sheng-Biao
Structural modification of oridonin via DAST induced rearrangement
title Structural modification of oridonin via DAST induced rearrangement
title_full Structural modification of oridonin via DAST induced rearrangement
title_fullStr Structural modification of oridonin via DAST induced rearrangement
title_full_unstemmed Structural modification of oridonin via DAST induced rearrangement
title_short Structural modification of oridonin via DAST induced rearrangement
title_sort structural modification of oridonin via dast induced rearrangement
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085272/
https://www.ncbi.nlm.nih.gov/pubmed/35547324
http://dx.doi.org/10.1039/c8ra05728a
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