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Exploring the binding mechanisms of PDE5 with chromeno[2,3-c]pyrrol-9(2H)-one by theoretical approaches

Cyclic nucleotide phosphodiesterase type 5 (PDE5), exclusively specific for the cyclic guanosine monophosphate (cGMP), is an important drug target for the treatment of erectile dysfunction and pulmonary arterial hypertension (PAH). Although many PDE5 inhibitors have been approved, such as sildenafil...

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Detalles Bibliográficos
Autores principales: Huang, Xianfeng, Xu, Peng, Cao, Yijing, Liu, Li, Song, Guoqiang, Xu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085377/
https://www.ncbi.nlm.nih.gov/pubmed/35546827
http://dx.doi.org/10.1039/c8ra06405a