Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol

An efficient and convenient method to construct tetracyclic isoquinolinium salts via [Cp*RhCl(2)](2) catalyzed C–H activation and [4 + 2] annulation reactions in ethanol is described. This reaction is very fast and highly efficient in the green solvent ethanol. The reaction works with a broad substr...

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Autores principales: Dang, Xinxin, He, Yu, Liu, Yingtian, Chen, Xuehong, Li, Jun-Long, Zhou, Xian-Li, Jiang, Hezhong, Li, Jiahong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085511/
https://www.ncbi.nlm.nih.gov/pubmed/35547300
http://dx.doi.org/10.1039/c8ra05443f
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author Dang, Xinxin
He, Yu
Liu, Yingtian
Chen, Xuehong
Li, Jun-Long
Zhou, Xian-Li
Jiang, Hezhong
Li, Jiahong
author_facet Dang, Xinxin
He, Yu
Liu, Yingtian
Chen, Xuehong
Li, Jun-Long
Zhou, Xian-Li
Jiang, Hezhong
Li, Jiahong
author_sort Dang, Xinxin
collection PubMed
description An efficient and convenient method to construct tetracyclic isoquinolinium salts via [Cp*RhCl(2)](2) catalyzed C–H activation and [4 + 2] annulation reactions in ethanol is described. This reaction is very fast and highly efficient in the green solvent ethanol. The reaction works with a broad substrate scope affording the products in good to excellent yields in a short time. Moreover, a ratio of S/C up to 10 000 could be achieved with gram scale synthesis.
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spelling pubmed-90855112022-05-10 Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol Dang, Xinxin He, Yu Liu, Yingtian Chen, Xuehong Li, Jun-Long Zhou, Xian-Li Jiang, Hezhong Li, Jiahong RSC Adv Chemistry An efficient and convenient method to construct tetracyclic isoquinolinium salts via [Cp*RhCl(2)](2) catalyzed C–H activation and [4 + 2] annulation reactions in ethanol is described. This reaction is very fast and highly efficient in the green solvent ethanol. The reaction works with a broad substrate scope affording the products in good to excellent yields in a short time. Moreover, a ratio of S/C up to 10 000 could be achieved with gram scale synthesis. The Royal Society of Chemistry 2018-08-24 /pmc/articles/PMC9085511/ /pubmed/35547300 http://dx.doi.org/10.1039/c8ra05443f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Dang, Xinxin
He, Yu
Liu, Yingtian
Chen, Xuehong
Li, Jun-Long
Zhou, Xian-Li
Jiang, Hezhong
Li, Jiahong
Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title_full Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title_fullStr Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title_full_unstemmed Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title_short Rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via C–H activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
title_sort rh(iii)-catalyzed synthesis of tetracyclic isoquinolinium salts via c–h activation and [4+2] annulation of 1-phenyl-3,4-dihydroisoquinolines and alkynes in ethanol
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085511/
https://www.ncbi.nlm.nih.gov/pubmed/35547300
http://dx.doi.org/10.1039/c8ra05443f
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