Targeting HMGA protein inhibits retinoblastoma cell proliferation

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

Detalles Bibliográficos
Autores principales: Balachandran, Akilandeswari, Zambre, Ajit, Kainth, Jagjot Singh, Nagarajha Selvan, Lakshmi Dhevi, Parameswaran, Sowmya, Afrasiabi, Zahra, Krishnakumar, Subramanian, Kannan, Raghuraman, Upendran, Anandhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085636/
https://www.ncbi.nlm.nih.gov/pubmed/35548247
http://dx.doi.org/10.1039/c8ra06026f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085636/
https://www.ncbi.nlm.nih.gov/pubmed/35548247
http://dx.doi.org/10.1039/c8ra06026f

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