Targeting HMGA protein inhibits retinoblastoma cell proliferation

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

Detalles Bibliográficos
Autores principales: Balachandran, Akilandeswari, Zambre, Ajit, Kainth, Jagjot Singh, Nagarajha Selvan, Lakshmi Dhevi, Parameswaran, Sowmya, Afrasiabi, Zahra, Krishnakumar, Subramanian, Kannan, Raghuraman, Upendran, Anandhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085636/
https://www.ncbi.nlm.nih.gov/pubmed/35548247
http://dx.doi.org/10.1039/c8ra06026f
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author Balachandran, Akilandeswari
Zambre, Ajit
Kainth, Jagjot Singh
Nagarajha Selvan, Lakshmi Dhevi
Parameswaran, Sowmya
Afrasiabi, Zahra
Krishnakumar, Subramanian
Kannan, Raghuraman
Upendran, Anandhi
author_facet Balachandran, Akilandeswari
Zambre, Ajit
Kainth, Jagjot Singh
Nagarajha Selvan, Lakshmi Dhevi
Parameswaran, Sowmya
Afrasiabi, Zahra
Krishnakumar, Subramanian
Kannan, Raghuraman
Upendran, Anandhi
author_sort Balachandran, Akilandeswari
collection PubMed
description We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.
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spelling pubmed-90856362022-05-10 Targeting HMGA protein inhibits retinoblastoma cell proliferation Balachandran, Akilandeswari Zambre, Ajit Kainth, Jagjot Singh Nagarajha Selvan, Lakshmi Dhevi Parameswaran, Sowmya Afrasiabi, Zahra Krishnakumar, Subramanian Kannan, Raghuraman Upendran, Anandhi RSC Adv Chemistry We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells. The Royal Society of Chemistry 2018-09-07 /pmc/articles/PMC9085636/ /pubmed/35548247 http://dx.doi.org/10.1039/c8ra06026f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Balachandran, Akilandeswari
Zambre, Ajit
Kainth, Jagjot Singh
Nagarajha Selvan, Lakshmi Dhevi
Parameswaran, Sowmya
Afrasiabi, Zahra
Krishnakumar, Subramanian
Kannan, Raghuraman
Upendran, Anandhi
Targeting HMGA protein inhibits retinoblastoma cell proliferation
title Targeting HMGA protein inhibits retinoblastoma cell proliferation
title_full Targeting HMGA protein inhibits retinoblastoma cell proliferation
title_fullStr Targeting HMGA protein inhibits retinoblastoma cell proliferation
title_full_unstemmed Targeting HMGA protein inhibits retinoblastoma cell proliferation
title_short Targeting HMGA protein inhibits retinoblastoma cell proliferation
title_sort targeting hmga protein inhibits retinoblastoma cell proliferation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085636/
https://www.ncbi.nlm.nih.gov/pubmed/35548247
http://dx.doi.org/10.1039/c8ra06026f
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