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Detecting Validated Intracellular ROS Generation with (18)F-dihydroethidine-Based PET
PURPOSE: To determine the sensitivity of the (18)F-radiolabelled dihydroethidine analogue ([(18)F]DHE) to ROS in a validated ex vivo model of tissue oxidative stress. PROCEDURES: The sensitivity of [(18)F]DHE to various ROS-generating systems was first established in vitro. Then, isolated rat hearts...
Autores principales: | Waters, Edward C. T., Baark, Friedrich, Yu, Zilin, Mota, Filipa, Eykyn, Thomas R., Yan, Ran, Southworth, Richard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085669/ https://www.ncbi.nlm.nih.gov/pubmed/34820762 http://dx.doi.org/10.1007/s11307-021-01683-0 |
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