Cargando…
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
Hypoxia-inducible factors (HIFs) are α/β heterodimeric transcription factors modulating cellular responses to the low oxygen condition. Among three HIF-α isoforms, HIF-3α is the least studied to date. Here we show that oleoylethanolamide (OEA), a physiological lipid known to regulate food intake and...
Autores principales: | Diao, Xiaotong, Ye, Fei, Zhang, Meina, Ren, Xintong, Tian, Xiaoxu, Lu, Jingping, Sun, Xiangnan, Hou, Zeng, Chen, Xiaoyu, Li, Fengwei, Zhuang, Jingjing, Ding, Hong, Peng, Chao, Rastinejad, Fraydoon, Luo, Cheng, Wu, Dalei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085743/ https://www.ncbi.nlm.nih.gov/pubmed/35534502 http://dx.doi.org/10.1038/s41467-022-30338-z |
Ejemplares similares
-
Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family
por: Sun, Xiangnan, et al.
Publicado: (2022) -
Bidirectional Modulation of HIF-2 Activity through Chemical Ligands
por: Wu, Dalei, et al.
Publicado: (2019) -
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors
por: Wu, Dalei, et al.
Publicado: (2016) -
The protein architecture and allosteric landscape of HNF4α
por: Rastinejad, Fraydoon
Publicado: (2023) -
Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
por: Chen, Ling, et al.
Publicado: (2015)