Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability

Despite the success of genome-wide association studies, much of the genetic contribution to complex traits remains unexplained. Here, we analyse high coverage whole-genome sequencing data, to evaluate the contribution of rare genetic variants to 414 plasma proteins. The frequency distribution of gen...

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Detalles Bibliográficos
Autores principales: Kierczak, Marcin, Rafati, Nima, Höglund, Julia, Gourlé, Hadrien, Lo Faro, Valeria, Schmitz, Daniel, Ek, Weronica E., Gyllensten, Ulf, Enroth, Stefan, Ekman, Diana, Nystedt, Björn, Karlsson, Torgny, Johansson, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085767/
https://www.ncbi.nlm.nih.gov/pubmed/35534486
http://dx.doi.org/10.1038/s41467-022-30208-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085767/
https://www.ncbi.nlm.nih.gov/pubmed/35534486
http://dx.doi.org/10.1038/s41467-022-30208-8

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