Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles

Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations due to an inheritance rate that surpasses Mendelian laws. However, this technology suffers from resistance alleles formed when the drive-induced DNA break is...

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Detalles Bibliográficos
Autores principales: Bishop, Alena L., López Del Amo, Víctor, Okamoto, Emily M., Bodai, Zsolt, Komor, Alexis C., Gantz, Valentino M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085836/
https://www.ncbi.nlm.nih.gov/pubmed/35534475
http://dx.doi.org/10.1038/s41467-022-29868-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085836/
https://www.ncbi.nlm.nih.gov/pubmed/35534475
http://dx.doi.org/10.1038/s41467-022-29868-3

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