Cargando…

Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy

Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint inhibitors. Although metabolic enzymes offer additional targets for therapy, the precise metabolic proteome of lung adenocarcinomas is unknown, hamper...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torresano, Laura, Santacatterina, Fulvio, Domínguez-Zorita, Sonia, Nuevo-Tapioles, Cristina, Núñez-Salgado, Alfonso, Esparza-Moltó, Pau B., González-Llorente, Lucía, Romero-Carramiñana, Inés, Núñez de Arenas, Cristina, Sánchez-Garrido, Brenda, Nájera, Laura, Salas, Clara, Provencio, Mariano, Cuezva, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085865/ https://www.ncbi.nlm.nih.gov/pubmed/35534478 http://dx.doi.org/10.1038/s41389-022-00400-y

Ejemplares similares

IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential
por: Romero-Carramiñana, Inés, et al.
Publicado: (2023)

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2023)

Regulation of the H(+)-ATP synthase by IF1: a role in mitohormesis
por: Esparza-Moltó, Pau B., et al.
Publicado: (2017)

Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
por: Nuevo-Tapioles, Cristina, et al.
Publicado: (2020)

The ATPase Inhibitory Factor 1 is a Tissue-Specific Physiological Regulator of the Structure and Function of Mitochondrial ATP Synthase: A Closer Look Into Neuronal Function
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2022)

Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells
por: González-Llorente, Lucía, et al.
Publicado: (2019)

Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease
por: Nuevo-Tapioles, Cristina, et al.
Publicado: (2021)

Quantitative analysis of proteins of metabolism by reverse phase protein microarrays identifies potential biomarkers of rare neuromuscular diseases
por: Santacatterina, Fulvio, et al.
Publicado: (2015)

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition
por: Esparza-Moltó, Pau B., et al.
Publicado: (2021)

The Role of Mitochondrial H(+)-ATP Synthase in Cancer
por: Esparza-Moltó, Pau B., et al.
Publicado: (2018)

Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis
por: Santacatterina, Fulvio, et al.
Publicado: (2017)

Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer
por: García-Ledo, Lucía, et al.
Publicado: (2017)

The role of KRAS splice variants in cancer biology
por: Nuevo-Tapioles, Cristina, et al.
Publicado: (2022)

Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle
por: Sánchez‐González, Cristina, et al.
Publicado: (2020)

Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
por: García-Navas, Rósula, et al.
Publicado: (2021)

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming
por: Prieto, Javier, et al.
Publicado: (2018)

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state
por: Santacatterina, Fulvio, et al.
Publicado: (2015)

Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition
por: Koplev, Simon, et al.
Publicado: (2018)

RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data
por: Shehwana, Huma, et al.
Publicado: (2022)

Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells
por: Mascaraque, Marta, et al.
Publicado: (2020)

Protein profiling by reverse phase protein array (RPPA) in classical hairy cell leukemia (HCL) and HCL‐variant
por: Hoff, Fieke W., et al.
Publicado: (2022)

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8(+) T lymphocytes
por: Ogando, Jesús, et al.
Publicado: (2019)

Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates
por: Sánchez-González, Cristina, et al.
Publicado: (2022)

Topological integration of RPPA proteomic data with multi-omics data for survival prediction in breast cancer via pathway activity inference
por: Kim, Tae Rim, et al.
Publicado: (2019)

The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2023)

Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the Voice Handicap Index
por: Núñez Batalla, Faustino, et al.
Publicado: (2007)

Schistosome-Associated Pulmonary Arterial Hypertension: A Review Emphasizing Pathogenesis
por: Ferrari, Teresa Cristina Abreu, et al.
Publicado: (2021)

Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate—Novel Insights
por: Povo-Retana, Adrián, et al.
Publicado: (2020)

Emergent Computation: Emphasizing Bioinformatics
por: Simon, Matthew
Publicado: (2005)

Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non- small cell lung cancer (NSCLC): a pilot study
por: Ludovini, Vienna, et al.
Publicado: (2017)

An opportunity to emphasize the relevance of laboratory medicine
por: Santamaría González, María, et al.
Publicado: (2021)

The mitochondrial ATP synthase is a shared drug target for aging and dementia
por: Goldberg, Joshua, et al.
Publicado: (2018)

Use of immune checkpoint inhibitors in patients with solid tumors and pre-existing autoimmune or inflammatory disease: real-world data
por: Calvo, Virginia, et al.
Publicado: (2021)

LHC computing stability emphasized at CHEP ’07
por: Silverman, Alan
Publicado: (2017)

Essentials of Zoology, Emphasizing Principles of Animal Biology
por: Merriman, Daniel
Publicado: (1941)

The Need to Emphasize Nephrology Knowledge in Residents-in-Training
por: Akbar, Sana R., et al.
Publicado: (2015)

DECAAF: Emphasizing the importance of MRI in AF ablation
por: ElMaghawry, Mohamed, et al.
Publicado: (2015)

Role of Clinical Endoscopy in Emphasizing Endoscope Disinfection
por: Ryu, Ji Kon, et al.
Publicado: (2015)

Head-Movement-Emphasized Rehabilitation in Bilateral Vestibulopathy
por: Lehnen, Nadine, et al.
Publicado: (2018)

Taxonomy of Phleboviruses, Emphasizing Those That Are Sandfly-Borne †
por: Calisher, Charles H., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_edon6dhsja8j8cjh4gepg6qvrl