Reaching alignment-profile-based accuracy in predicting protein secondary and tertiary structural properties without alignment

Protein language models have emerged as an alternative to multiple sequence alignment for enriching sequence information and improving downstream prediction tasks such as biophysical, structural, and functional properties. Here we show that a method called SPOT-1D-LM combines traditional one-hot enc...

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Detalles Bibliográficos
Autores principales: Singh, Jaspreet, Paliwal, Kuldip, Litfin, Thomas, Singh, Jaswinder, Zhou, Yaoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085874/
https://www.ncbi.nlm.nih.gov/pubmed/35534620
http://dx.doi.org/10.1038/s41598-022-11684-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085874/
https://www.ncbi.nlm.nih.gov/pubmed/35534620
http://dx.doi.org/10.1038/s41598-022-11684-w

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