Sulfur(vi) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure–activity relationship studies

Extremely potent, new hepatitis C virus (HCV) nonstructural 5A (NS5A) featuring substituted biaryl sulfate core structures was designed and synthesized. Based on the previously reported novel HCV NS5A inhibitors featuring biaryl sulfate core structures which exhibit two-digit picomolar half-maximal...

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Detalles Bibliográficos
Autores principales: You, Youngsu, Kim, Hee Sun, Park, Jung Woo, Keum, Gyochang, Jang, Sung Key, Kim, B. Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085918/
https://www.ncbi.nlm.nih.gov/pubmed/35548241
http://dx.doi.org/10.1039/c8ra05471a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085918/
https://www.ncbi.nlm.nih.gov/pubmed/35548241
http://dx.doi.org/10.1039/c8ra05471a

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