Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity

The anti-oncogenic protein p53 is a transcription factor that prevents tumorigenesis by inducing gene repair proteins or apoptosis under DNA damage. Since the DNA-binding domain of p53 (p53C) is aggregation-prone, the anti-oncogenic function of p53 is often lost in cancer cells. This tendency is rat...

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Detalles Bibliográficos
Autores principales: Hibino, Emi, Tenno, Takeshi, Hiroaki, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086241/
https://www.ncbi.nlm.nih.gov/pubmed/35558561
http://dx.doi.org/10.3389/fmolb.2022.869851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086241/
https://www.ncbi.nlm.nih.gov/pubmed/35558561
http://dx.doi.org/10.3389/fmolb.2022.869851

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