Corroboration of Zn(ii)–Mg(ii)-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme

The TW17 ribozyme, a catalytic RNA selected from a pool of artificial RNA, is specific for the Zn(2+)-dependent hydrolysis of a phosphorothiolate thiolester bond. Here, we describe the organic synthesis of both guanosine α-thio-monophosphate and the substrates required for selecting and characterizi...

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Detalles Bibliográficos
Autores principales: Wang, Tzu-Pin, Su, Yu-Chih, Chen, Yi, Severance, Scott, Hwang, Chi-Ching, Liou, Yi-Ming, Lu, Chia-Hui, Lin, Kun-Liang, Zhu, Rui Jing, Wang, Eng-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086351/
https://www.ncbi.nlm.nih.gov/pubmed/35547718
http://dx.doi.org/10.1039/c8ra05083j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086351/
https://www.ncbi.nlm.nih.gov/pubmed/35547718
http://dx.doi.org/10.1039/c8ra05083j

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