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A Kv2 inhibitor traps itself in place
Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086499/ https://www.ncbi.nlm.nih.gov/pubmed/35522189 http://dx.doi.org/10.1085/jgp.202213181 |