A Kv2 inhibitor traps itself in place

Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.

Detalles Bibliográficos
Autor principal: Short, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Research News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086499/
https://www.ncbi.nlm.nih.gov/pubmed/35522189
http://dx.doi.org/10.1085/jgp.202213181
Descripción
Sumario:Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.

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