A Kv2 inhibitor traps itself in place

Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.

Detalles Bibliográficos
Autor principal: Short, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Research News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086499/
https://www.ncbi.nlm.nih.gov/pubmed/35522189
http://dx.doi.org/10.1085/jgp.202213181
_version_ 1784704015859187712
author Short, Ben
author_facet Short, Ben
author_sort Short, Ben
collection PubMed
description Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.
format Online
Article
Text
id pubmed-9086499
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-90864992022-12-06 A Kv2 inhibitor traps itself in place Short, Ben J Gen Physiol Research News Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place. Rockefeller University Press 2022-05-06 /pmc/articles/PMC9086499/ /pubmed/35522189 http://dx.doi.org/10.1085/jgp.202213181 Text en © 2022 Rockefeller University Press https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research News
Short, Ben
A Kv2 inhibitor traps itself in place
title A Kv2 inhibitor traps itself in place
title_full A Kv2 inhibitor traps itself in place
title_fullStr A Kv2 inhibitor traps itself in place
title_full_unstemmed A Kv2 inhibitor traps itself in place
title_short A Kv2 inhibitor traps itself in place
title_sort kv2 inhibitor traps itself in place
topic Research News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086499/
https://www.ncbi.nlm.nih.gov/pubmed/35522189
http://dx.doi.org/10.1085/jgp.202213181
work_keys_str_mv AT shortben akv2inhibitortrapsitselfinplace
AT shortben kv2inhibitortrapsitselfinplace

Ejemplares similares