Biophysical evaluation to categorize pathogenicity of cancer-predisposing mutations identified in the BARD1 BRCT domain

The BRCT domain of BARD1 (BARD1 BRCT) is involved in many cellular processes such as DNA damage repair (DDR) and cell-cycle checkpoint regulation. BARD1 BRCT performs tumor suppressor function by recruiting BRCA1 at DNA damage site via interactions with other DNA damage repair (DDR) proteins. Consid...

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Detalles Bibliográficos
Autores principales: Choudhary, Rajan Kumar, Siddiqui, M. Quadir, Gadewal, Nikhil, Kumar, Nachimuthu Senthil, Kuligina, Ekaterina S., Varma, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086705/
https://www.ncbi.nlm.nih.gov/pubmed/35548793
http://dx.doi.org/10.1039/c8ra06524a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086705/
https://www.ncbi.nlm.nih.gov/pubmed/35548793
http://dx.doi.org/10.1039/c8ra06524a

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