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Biophysical evaluation to categorize pathogenicity of cancer-predisposing mutations identified in the BARD1 BRCT domain

The BRCT domain of BARD1 (BARD1 BRCT) is involved in many cellular processes such as DNA damage repair (DDR) and cell-cycle checkpoint regulation. BARD1 BRCT performs tumor suppressor function by recruiting BRCA1 at DNA damage site via interactions with other DNA damage repair (DDR) proteins. Consid...

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Detalles Bibliográficos
Autores principales:	Choudhary, Rajan Kumar, Siddiqui, M. Quadir, Gadewal, Nikhil, Kumar, Nachimuthu Senthil, Kuligina, Ekaterina S., Varma, Ashok K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086705/ https://www.ncbi.nlm.nih.gov/pubmed/35548793 http://dx.doi.org/10.1039/c8ra06524a

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