Identification of the cytochrome P450 enzymes involved in the oxidative metabolism of trantinterol using ultra high-performance liquid chromatography coupled with tandem mass spectrometry

Trantinterol is a novel β(2)-adrenoceptor agonist used for the treatment of asthma. This study aimed to identify the cytochrome P450 enzymes responsible for the metabolism of trantinterol to form 4-hydroxylamine trantinterol (M1) and tert-butyl hydroxylated trantinterol (M2), which was achieved usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Kunjie, Guo, Xingjie, Qin, Feng, Xiong, Zhili, Zhao, Longshan, Yu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086916/
https://www.ncbi.nlm.nih.gov/pubmed/35548639
http://dx.doi.org/10.1039/c8ra06219f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086916/
https://www.ncbi.nlm.nih.gov/pubmed/35548639
http://dx.doi.org/10.1039/c8ra06219f

Ejemplares similares