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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
Steroid 5β-reductase (AKR1D1) plays important role in hepatic bile acid synthesis and glucocorticoid clearance. Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. Akr1d1(–/–) mice were generated on a C57BL/6 background....
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086936/ https://www.ncbi.nlm.nih.gov/pubmed/35318963 http://dx.doi.org/10.1530/JOE-21-0280 |