T-Cell Heterogeneity in Baseline Tumor Samples: Implications for Early Clinical Trial Design and Analysis

BACKGROUND: In early stage clinical trials, changes to levels of tumor infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) are critical biomarkers of the mechanism of action of novel immunotherapies. However, baseline heterogeneity of tumor samples, both between and within patients,...

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Detalles Bibliográficos
Autores principales: Brennan, Laura, Brouwer-Visser, Jurriaan, Nüesch, Eveline, Karpova, Maria, Heller, Astrid, Gaire, Fabien, Schneider, Meike, Gomes, Bruno, Korski, Konstanty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086966/
https://www.ncbi.nlm.nih.gov/pubmed/35558070
http://dx.doi.org/10.3389/fimmu.2022.760763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086966/
https://www.ncbi.nlm.nih.gov/pubmed/35558070
http://dx.doi.org/10.3389/fimmu.2022.760763

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