Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C–H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel...

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Autores principales: Novikova, Daria S., Grigoreva, Tatyana A., Zolotarev, Andrey A., Garabadzhiu, Alexander V., Tribulovich, Vyacheslav G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086994/
https://www.ncbi.nlm.nih.gov/pubmed/35548634
http://dx.doi.org/10.1039/c8ra07576j
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author Novikova, Daria S.
Grigoreva, Tatyana A.
Zolotarev, Andrey A.
Garabadzhiu, Alexander V.
Tribulovich, Vyacheslav G.
author_facet Novikova, Daria S.
Grigoreva, Tatyana A.
Zolotarev, Andrey A.
Garabadzhiu, Alexander V.
Tribulovich, Vyacheslav G.
author_sort Novikova, Daria S.
collection PubMed
description A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C–H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.
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spelling pubmed-90869942022-05-10 Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction Novikova, Daria S. Grigoreva, Tatyana A. Zolotarev, Andrey A. Garabadzhiu, Alexander V. Tribulovich, Vyacheslav G. RSC Adv Chemistry A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C–H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work. The Royal Society of Chemistry 2018-10-10 /pmc/articles/PMC9086994/ /pubmed/35548634 http://dx.doi.org/10.1039/c8ra07576j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Novikova, Daria S.
Grigoreva, Tatyana A.
Zolotarev, Andrey A.
Garabadzhiu, Alexander V.
Tribulovich, Vyacheslav G.
Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title_full Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title_fullStr Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title_full_unstemmed Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title_short Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction
title_sort advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted knoevenagel reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086994/
https://www.ncbi.nlm.nih.gov/pubmed/35548634
http://dx.doi.org/10.1039/c8ra07576j
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