Predicting Approximate Clinically Effective Doses in Oncology Using Preclinical Efficacy and Body Surface Area Conversion: A Retrospective Analysis

The correlation between efficacious doses in human tumor-xenograft mouse models and the human clinical doses of approved oncology agents was assessed using published preclinical data and recommended clinical doses. For 90 approved small molecule anti-cancer drugs, body surface area (BSA) corrected m...

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Detalles Bibliográficos
Autores principales: Griffin, Robert J., Avery, Ethan, Xia, Cindy Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087189/
https://www.ncbi.nlm.nih.gov/pubmed/35559235
http://dx.doi.org/10.3389/fphar.2022.830972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087189/
https://www.ncbi.nlm.nih.gov/pubmed/35559235
http://dx.doi.org/10.3389/fphar.2022.830972

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