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A Computational Model for the PLP-Dependent Enzyme Methionine γ-Lyase

Pyridoxal-5′-phosphate (PLP) is a cofactor in the reactions of over 160 enzymes, several of which are implicated in diseases. Methionine γ-lyase (MGL) is of interest as a therapeutic protein for cancer treatment. It binds PLP covalently through a Schiff base linkage and digests methionine, whose dep...

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Detalles Bibliográficos
Autores principales: Chen, Xingyu, Briozzo, Pierre, Machover, David, Simonson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087591/
https://www.ncbi.nlm.nih.gov/pubmed/35558556
http://dx.doi.org/10.3389/fmolb.2022.886358