Cargando…

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

[Image: see text] A selection of compounds from a proprietary library, based on chemical diversity and various biological activities, was evaluated as potential inhibitors of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a phenotypic-based screening assay. A compound based on a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nizi, Maria Giulia, Persoons, Leentje, Corona, Angela, Felicetti, Tommaso, Cernicchi, Giada, Massari, Serena, Manfroni, Giuseppe, Vangeel, Laura, Barreca, Maria Letizia, Esposito, Francesca, Jochmans, Dirk, Milia, Jessica, Cecchetti, Violetta, Schols, Dominique, Neyts, Johan, Tramontano, Enzo, Sabatini, Stefano, De Jonghe, Steven, Tabarrini, Oriana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088073/ https://www.ncbi.nlm.nih.gov/pubmed/35571875 http://dx.doi.org/10.1021/acsmedchemlett.2c00123

Ejemplares similares

From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search
por: Cedraro, Nicholas, et al.
Publicado: (2021)

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
por: Massari, Serena, et al.
Publicado: (2018)

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
por: Desantis, Jenny, et al.
Publicado: (2020)

Inhibition of Influenza Virus Polymerase by Interfering with Its Protein–Protein Interactions
por: Massari, Serena, et al.
Publicado: (2020)

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors
por: Cannalire, Rolando, et al.
Publicado: (2020)

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors
por: Felicetti, Tommaso, et al.
Publicado: (2020)

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli
por: Machado, Diana, et al.
Publicado: (2017)

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
por: Massari, Serena, et al.
Publicado: (2021)

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues
por: Persoons, Leentje, et al.
Publicado: (2021)

Modulating microRNA Processing: Enoxacin, the Progenitor of a New Class of Drugs
por: Felicetti, Tommaso, et al.
Publicado: (2020)

New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors
por: Manfroni, Giuseppe, et al.
Publicado: (2014)

Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives
por: Cernicchi, Giada, et al.
Publicado: (2021)

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations
por: Palazzotti, Deborah, et al.
Publicado: (2023)

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs
por: Nizi, Maria Giulia, et al.
Publicado: (2023)

Inhibition of Staphylococcus pseudintermedius Efflux Pumps by Using Staphylococcus aureus NorA Efflux Pump Inhibitors
por: Rampacci, Elisa, et al.
Publicado: (2023)

Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
por: Nizi, Maria Giulia, et al.
Publicado: (2022)

Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model
por: Foo, Caroline S., et al.
Publicado: (2022)

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach
por: Palazzotti, Deborah, et al.
Publicado: (2019)

Discovery of ( ±)-3-(1 H -pyrazol-1-yl)-6,7-dihydro-5 H -[1,2,4]triazolo[3,4- b ][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity
por: Jilloju, Parameshwara Chary, et al.
Publicado: (2021)

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening
por: Astolfi, Andrea, et al.
Publicado: (2015)

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
por: Vangeel, Laura, et al.
Publicado: (2022)

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Itaconic acid hybrids as potential anticancer agents
por: Perković, Ivana, et al.
Publicado: (2020)

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase
por: Kasprzyk, Renata, et al.
Publicado: (2021)

Synthesis of Substituted 2-Pyridyl-4-phenylquinolines
por: Mamo, Antonino, et al.
Publicado: (2002)

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
por: Gao, Shenghua, et al.
Publicado: (2022)

Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery
por: Chiu, Winston, et al.
Publicado: (2023)

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells
por: Vanhoutte, Roeland, et al.
Publicado: (2023)

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort
por: Zaliani, Andrea, et al.
Publicado: (2022)

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents
por: Do, Thuc Nguyen Dan, et al.
Publicado: (2021)

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia
por: Astolfi, Andrea, et al.
Publicado: (2022)

7-Methoxy-2-phenylquinoline-3-carbaldehyde
por: Hayour, Hasna, et al.
Publicado: (2014)

Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles
por: Das, Arnika, et al.
Publicado: (2021)

SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells
por: Do, Thuc Nguyen Dan, et al.
Publicado: (2022)

Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
por: Boniardi, Irene, et al.
Publicado: (2023)

2-Bromo-5,7-dimethoxy-4-phenylquinoline
por: Gopal, Veshal, et al.
Publicado: (2009)

Ethyl 2-methyl-4-phenylquinoline-3-carboxylate
por: Bazgir, Ayoob
Publicado: (2009)

N-Isopropyl-6-methyl-2-phenylquinoline-3-carboxamide
por: Benzerka, Saida, et al.
Publicado: (2010)

4-Methyl-1-phenylquinolin-2(1H)-one
por: Petrov, Petar Yotov, et al.
Publicado: (2007)

Pharmacological Agents Targeting the Cellular Prion Protein
por: Barreca, Maria Letizia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8vqut9c36gkkn8qkuns3qt8q3h