Cargando…

Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer

BACKGROUND: Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the underlying mechanism of gemcitabine resistance remains unclear. Various factors, s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Jianyou, Huang, Wenjie, Wang, Xianxing, Zhang, Junfeng, Tao, Tian, Zheng, Yao, Liu, Songsong, Yang, Jiali, Chen, Zhe-Sheng, Cai, Chao-Yun, Li, Jinsui, Wang, Huaizhi, Fan, Yingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088115/ https://www.ncbi.nlm.nih.gov/pubmed/35538494 http://dx.doi.org/10.1186/s12943-022-01587-9

Ejemplares similares

TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway
por: Gu, Jianyou, et al.
Publicado: (2021)

Activating miRNA-mRNA network in gemcitabine-resistant pancreatic cancer cell associates with alteration of memory CD4(+) T cells
por: Gu, Jianyou, et al.
Publicado: (2020)

Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA
por: Zhang, Junfeng, et al.
Publicado: (2020)

The RhoB small GTPase in physiology and disease
por: Vega, Francisco M., et al.
Publicado: (2016)

MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation
por: Huang, Wenjie, et al.
Publicado: (2020)

RhoA, RhoB and RhoC differentially regulate endothelial barrier function
por: Pronk, Manon C. A., et al.
Publicado: (2017)

RhoB: Team Oncogene or Team Tumor Suppressor?
por: Ju, Julia A., et al.
Publicado: (2018)

hsa-miR-3177-5p and hsa-miR-3178 Inhibit 5-HT1A Expression by Binding the 3′-UTR Region in vitro
por: Wu, Xue, et al.
Publicado: (2019)

Epigenetic regulation of RhoB loss of expression in lung cancer
por: Mazières, Julien, et al.
Publicado: (2007)

The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion
por: Liu, Songsong, et al.
Publicado: (2020)

Corrigendum: The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
por: Xie, Fuming, et al.
Publicado: (2023)

The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
por: Xie, Fuming, et al.
Publicado: (2023)

The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction
por: Vega, Francisco M, et al.
Publicado: (2015)

RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA
por: Howe, Grant A, et al.
Publicado: (2012)

RhoB affects colitis through modulating cell signaling and intestinal microbiome
por: Yang, Jianming, et al.
Publicado: (2022)

Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice
por: Englert, Maximilian, et al.
Publicado: (2022)

Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients
por: Yang, Jiali, et al.
Publicado: (2022)

RhoB regulates cell migration through altered focal adhesion dynamics
por: Vega, Francisco M., et al.
Publicado: (2012)

Rnd3 induces stress fibres in endothelial cells through RhoB
por: Gottesbühren, Undine, et al.
Publicado: (2012)

Expression Loss and Revivification of RhoB Gene in Ovary Carcinoma Carcinogenesis and Development
por: Liu, Yingwei, et al.
Publicado: (2013)

The Small GTPase RhoB Regulates TNFα Signaling in Endothelial Cells
por: Kroon, Jeffrey, et al.
Publicado: (2013)

p27(Kip1) – p(RhoB)lematic in lung cancer
por: Podmirseg, Silvio R, et al.
Publicado: (2019)

Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma
por: Arildsen, Nicolai Skovbjerg, et al.
Publicado: (2017)

Arf6 regulates RhoB subcellular localization to control cancer cell invasion
por: Zaoui, Kossay, et al.
Publicado: (2019)

Alteration of tumor-associated macrophage subtypes mediated by KRT6A in pancreatic ductal adenocarcinoma
por: Zhang, Junfeng, et al.
Publicado: (2020)

Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway
por: Chi, Bojing, et al.
Publicado: (2022)

Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells
por: de León-Bautista, Mercedes Piedad, et al.
Publicado: (2016)

Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells
por: Diao, Fei, et al.
Publicado: (2017)

Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model
por: Delord, J-P, et al.
Publicado: (2010)

Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB)
por: Ma, Qing, et al.
Publicado: (2019)

A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors
por: Privat, Maud, et al.
Publicado: (2020)

The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
por: Pérez-Sala, Dolores, et al.
Publicado: (2009)

MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells
por: Sabatel, Céline, et al.
Publicado: (2011)

Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-Regulation
por: Majhen, Dragomira, et al.
Publicado: (2014)

RhoB modifies estrogen responses in breast cancer cells by influencing expression of the estrogen receptor
por: Médale-Giamarchi, Claire, et al.
Publicado: (2013)

RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border
por: Marcos-Ramiro, Beatriz, et al.
Publicado: (2016)

Activation of the RhoB Signaling Pathway by Thyroid Hormone Receptor β in Thyroid Cancer Cells
por: Ichijo, Sayaka, et al.
Publicado: (2014)

RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus
por: Mandik-Nayak, Laura, et al.
Publicado: (2017)

MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer
por: Hu, You, et al.
Publicado: (2022)

The mechanisms and significance of up‐regulation of RhoB expression by hypoxia and glucocorticoid in rat lung and A549 cells
por: Huang, Gao‐Xiang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p6fbi8n4br9am2l9ocnnjl9o1i