Cargando…

PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

OBJECTIVE: Glycogen synthase kinase-3β (GSK3β) has been recognized as a suppressor of Wnt/β-catenin signaling, which is critical for the stemness maintenance of breast cancer stem cells. However, the regulatory mechanisms of GSK3β protein expression remain elusive. METHODS: Co-immunoprecipitation an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Wei, Wu, Yu, Qi, Xin, Yu, Rilei, Lu, Zhimin, Chen, Ao, Fan, Xinglong, Li, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Compuscript 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088184/ https://www.ncbi.nlm.nih.gov/pubmed/34403222 http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0362

Ejemplares similares

Hsp90 Maintains the Stability and Function of the Tau Phosphorylating Kinase GSK3β
por: Dou, Fei, et al.
Publicado: (2007)

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β
por: Wang, Chongyang, et al.
Publicado: (2023)

PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma
por: Zhou, Jing-Wei, et al.
Publicado: (2019)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
por: Chang, Cheng, et al.
Publicado: (2023)

A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6
por: Liao, Liping, et al.
Publicado: (2022)

HSP90 facilitates stemness and enhances glycolysis in glioma cells
por: Kang, Xun, et al.
Publicado: (2022)

Protein Stability, Folding and Misfolding in Human PGK1 Deficiency
por: Valentini, Giovanna, et al.
Publicado: (2013)

Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis
por: Shao, Fei, et al.
Publicado: (2019)

Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation
por: Huang, Jiawen, et al.
Publicado: (2018)

Distinct Roles of Molecular Chaperones HSP90α and HSP90β in the Biogenesis of KCNQ4 Channels
por: Gao, Yanhong, et al.
Publicado: (2013)

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
por: Kuroyanagi, Gen, et al.
Publicado: (2022)

The Discovery of Novel PGK1 Activators as Apoptotic Inhibiting and Neuroprotective Agents
por: Qiang, Shao-Jia, et al.
Publicado: (2022)

SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90
por: Lian, Bin, et al.
Publicado: (2021)

The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice
por: Hong, Liang-Jian, et al.
Publicado: (2020)

HSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma
por: Liu, Hui-Qi, et al.
Publicado: (2023)

Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90α and Hsp90β to the cell plasma membrane
por: Snigireva, Anastasiya V, et al.
Publicado: (2015)

LncRNA NEAT1 facilitates glioma progression via stabilizing PGK1
por: Liang, Jingshan, et al.
Publicado: (2022)

The Role of HSP90 Inhibitors in the Treatment of Cardiovascular Diseases
por: Qi, Shiyu, et al.
Publicado: (2022)

mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs
por: Chen, Zhenzhen, et al.
Publicado: (2023)

Enhancing viability and angiogenic efficacy of mesenchymal stem cells via HSP90α and HSP27 regulation based on ROS stimulation for wound healing
por: Seo, Inwoo, et al.
Publicado: (2023)

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β
por: Peng, Yi-Jheng, et al.
Publicado: (2016)

Production and purification of human Hsp90β in Escherichia coli
por: Radli, Martina, et al.
Publicado: (2017)

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
por: Zhao, X M, et al.
Publicado: (2016)

HSP-90/kinase complexes are stabilized by the large PPIase FKB-6
por: Sima, Siyuan, et al.
Publicado: (2021)

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer
por: Cheng, An Ning, et al.
Publicado: (2017)

Assessment of heat shock protein (HSP60, HSP72, HSP90, and HSC70) expression in cultured limbal stem cells following air lifting
por: Ebrahimi, Marzeih, et al.
Publicado: (2010)

C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity
por: Fan, Yingjuan, et al.
Publicado: (2017)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

Diagnostic value of HSP90α and related markers in lung cancer
por: Yuan, Zhimin, et al.
Publicado: (2022)

Quantification of Hsp90 availability reveals differential coupling to the heat shock response
por: Alford, Brian D., et al.
Publicado: (2018)

Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors
por: Yuan, Zhimin, et al.
Publicado: (2022)

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90
por: Morgner, Nina, et al.
Publicado: (2015)

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
por: Shen, Shensi, et al.
Publicado: (2009)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Mechanisms of Hsp90 regulation
por: Prodromou, Chrisostomos
Publicado: (2016)

Regulatory Mechanisms of Hsp90
por: Prodromou, Chrisostomos
Publicado: (2017)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

Role of HSP90 in Cancer
por: Birbo, Bereket, et al.
Publicado: (2021)

Organismal Roles of Hsp90
por: van Oosten-Hawle, Patricija
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hv764smg160pt1e9itcrklvr4u