A Facile Platform to Engineer Escherichia coli Tyrosyl-tRNA Synthetase Adds New Chemistries to the Eukaryotic Genetic Code, Including a Phosphotyrosine Mimic

[Image: see text] The Escherichia coli tyrosyl-tRNA synthetase (EcTyrRS)/tRNA(EcTyr) pair offers an attractive platform for genetically encoding new noncanonical amino acids (ncAA) in eukaryotes. However, challenges associated with a eukaryotic selection system, which is needed to engineer the platf...

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Detalles Bibliográficos
Autores principales: Grasso, Katherine T., Singha Roy, Soumya Jyoti, Osgood, Arianna O., Yeo, Megan Jin Rae, Soni, Chintan, Hillenbrand, Christen M., Ficaretta, Elise D., Chatterjee, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088295/
https://www.ncbi.nlm.nih.gov/pubmed/35559426
http://dx.doi.org/10.1021/acscentsci.1c01465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088295/
https://www.ncbi.nlm.nih.gov/pubmed/35559426
http://dx.doi.org/10.1021/acscentsci.1c01465

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