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A Facile Platform to Engineer Escherichia coli Tyrosyl-tRNA Synthetase Adds New Chemistries to the Eukaryotic Genetic Code, Including a Phosphotyrosine Mimic
[Image: see text] The Escherichia coli tyrosyl-tRNA synthetase (EcTyrRS)/tRNA(EcTyr) pair offers an attractive platform for genetically encoding new noncanonical amino acids (ncAA) in eukaryotes. However, challenges associated with a eukaryotic selection system, which is needed to engineer the platf...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088295/ https://www.ncbi.nlm.nih.gov/pubmed/35559426 http://dx.doi.org/10.1021/acscentsci.1c01465 |