An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity

[Image: see text] We report the development of a high-throughput, intracellular “transcription block survival” (TBS) screening platform to derive functional transcription factor antagonists. TBS is demonstrated using the oncogenic transcriptional regulator cJun, with the development of antagonists t...

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Detalles Bibliográficos
Autores principales: Brennan, Andrew, Leech, James T., Kad, Neil M., Mason, Jody M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088798/
https://www.ncbi.nlm.nih.gov/pubmed/35557753
http://dx.doi.org/10.1021/jacsau.2c00105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088798/
https://www.ncbi.nlm.nih.gov/pubmed/35557753
http://dx.doi.org/10.1021/jacsau.2c00105

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