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Molecular dynamics derived life times of active substrate binding poses explain K(M) of laccase mutants
Fungal laccases (EC 1.10.3.2) are important multi-copper oxidases with broad substrate specificity. Laccases from Trametes versicolor (TvL) are among the best-characterized of these enzymes. Mutations in the substrate-binding site of TvL substantially affect K(M), but a molecular understanding of th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089231/ https://www.ncbi.nlm.nih.gov/pubmed/35558910 http://dx.doi.org/10.1039/c8ra07138a |