Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells

The Three Prime Repair EXonuclease I (TREX1) is critical for degrading post‐apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus‐like autoimmunity due to chronic sensing of undegraded TREX1 DNA substrates, production of the inflammatory cytokines, and the inappropri...

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Detalles Bibliográficos
Autores principales: Venkatadri, Rajkumar, Sabapathy, Vikram, Dogan, Murat, Mohammad, Saleh, Harvey, Scott E., Simpson, Sean R., Grayson, Jason M., Yan, Nan, Perrino, Fred W., Sharma, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Immunodeficiencies and autoimmunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089306/
https://www.ncbi.nlm.nih.gov/pubmed/35112355
http://dx.doi.org/10.1002/eji.202149324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089306/
https://www.ncbi.nlm.nih.gov/pubmed/35112355
http://dx.doi.org/10.1002/eji.202149324

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