Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization

[Image: see text] Protein tyrosine phosphatases (PTPs), the enzymes that catalyze the dephosphorylation of phosphotyrosine residues, are important regulators of mammalian cell signaling, whose activity is misregulated in numerous human diseases. PTPs are also notoriously difficult to selectively mod...

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Detalles Bibliográficos
Autores principales: Buck, Sara J. S., Plaman, Bailey A., Bishop, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089384/
https://www.ncbi.nlm.nih.gov/pubmed/35559188
http://dx.doi.org/10.1021/acsomega.2c00780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089384/
https://www.ncbi.nlm.nih.gov/pubmed/35559188
http://dx.doi.org/10.1021/acsomega.2c00780

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