Massively-parallel enrichment of minor alleles for mutational testing via low-depth duplex sequencing

The ability to assay large numbers of low-frequency mutations is useful in biomedicine, yet, the technical hurdles of sequencing multiple mutations at extremely high depth, with accuracy, limits their detection in clinical practice. Low-frequency mutations can typically be detected by increasing the...

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Detalles Bibliográficos
Autores principales: Gydush, Gregory, Nguyen, Erica, Bae, Jin H., Blewett, Timothy, Rhoades, Justin, Reed, Sarah C., Shea, Douglas, Xiong, Kan, Liu, Ruolin, Yu, Fangyan, Leong, Ka Wai, Choudhury, Atish D., Stover, Daniel G., Tolaney, Sara M., Krop, Ian E., Love, J. Christopher, Parsons, Heather A., Makrigiorgos, G. Mike, Golub, Todd R., Adalsteinsson, Viktor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089460/
https://www.ncbi.nlm.nih.gov/pubmed/35301450
http://dx.doi.org/10.1038/s41551-022-00855-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089460/
https://www.ncbi.nlm.nih.gov/pubmed/35301450
http://dx.doi.org/10.1038/s41551-022-00855-9

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