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Heterogeneity and clonality of kidney-infiltrating T cells in murine lupus nephritis

We previously found that kidney-infiltrating T cells (KITs) in murine lupus nephritis (LN) resembled dysfunctional T cells that infiltrate tumors. This unexpected finding raised the question of how to reconcile the “exhausted” phenotype of KITs with ongoing tissue destruction in LN. To address this,...

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Detalles Bibliográficos
Autores principales: Smita, Shuchi, Chikina, Maria, Shlomchik, Mark J., Tilstra, Jeremy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089785/
https://www.ncbi.nlm.nih.gov/pubmed/35271505
http://dx.doi.org/10.1172/jci.insight.156048