Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder. As disease progresses, motor neurons are affected, and their dysfunction contributes toward the inability to maintain proper respiratory function, a major driving force for premature death in SCA1. To investigate the...

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Detalles Bibliográficos
Autores principales: Orengo, James P., Nitschke, Larissa, van der Heijden, Meike E., Ciaburri, Nicholas A., Orr, Harry T., Zoghbi, Huda Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Resource and Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089789/
https://www.ncbi.nlm.nih.gov/pubmed/35290244
http://dx.doi.org/10.1172/jci.insight.154442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089789/
https://www.ncbi.nlm.nih.gov/pubmed/35290244
http://dx.doi.org/10.1172/jci.insight.154442

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