Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Chronic myeloproliferative neoplasms (MPN) frequently evolve to a blast phase (BP) that is almost uniformly resistant to induction chemotherapy or hypomethylating agents. We explored the functional properties, genomic architecture, and cell of origin of MPN-BP initiating cells (IC) using a serial NS...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoli, Rampal, Raajit K., Hu, Cing Siang, Tripodi, Joseph, Farnoud, Noushin, Petersen, Bruce, Rossi, Michael R., Patel, Minal, McGovern, Erin, Najfeld, Vesna, Iancu-Rubin, Camelia, Lu, Min, Davis, Andrew, Kremyanskaya, Marina, Weinberg, Rona Singer, Mascarenhas, John, Hoffman, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089790/
https://www.ncbi.nlm.nih.gov/pubmed/35259128
http://dx.doi.org/10.1172/jci.insight.156534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089790/
https://www.ncbi.nlm.nih.gov/pubmed/35259128
http://dx.doi.org/10.1172/jci.insight.156534

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