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The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis

Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely associated with arthritis, are contributors and sensors of inflammation through epigenetic modifications. In this...

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Detalles Bibliográficos
Autores principales: de la Calle-Fabregat, Carlos, Rodríguez-Ubreva, Javier, Ciudad, Laura, Ramírez, Julio, Celis, Raquel, Azuaga, Ana Belén, Cuervo, Andrea, Graell, Eduard, Pérez-García, Carolina, Díaz-Torné, César, Salvador, Georgina, Gómez-Puerta, José A., Haro, Isabel, Sanmartí, Raimon, Cañete, Juan D., Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090240/
https://www.ncbi.nlm.nih.gov/pubmed/35324478
http://dx.doi.org/10.1172/jci.insight.158783