UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner

It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen and other extracellular matrix components to produce wrinkles. However, these...

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Detalles Bibliográficos
Autores principales: Kim, Daniel J., Iwasaki, Akiko, Chien, Anna L., Kang, Sewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090247/
https://www.ncbi.nlm.nih.gov/pubmed/35316219
http://dx.doi.org/10.1172/jci.insight.156344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090247/
https://www.ncbi.nlm.nih.gov/pubmed/35316219
http://dx.doi.org/10.1172/jci.insight.156344

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